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目的比较不同间断静脉滴注哌拉西林/他唑巴坦治疗老年医院获得性肺炎(HAP)的临床效果及安全性。方法将老年HAP随机分为两组,对照组予哌拉西林/他唑巴坦2.5g,1次/8h,试验组予哌拉西林/他唑巴坦3.75g,1次/12h,加入生理盐水100ml中静脉滴注,疗程均为10～14d。结果试验组与对照组的临床治愈率、总有效率、细菌清除率分别为51.43%、82.86%、80.00%和52.78%、83.33%、80.56%,药物相关不良反应发生率为8.57%和8.33%,两组差异均无统计学意义;不良反应主要为轻微胃肠不适、肝功能损害及白细胞减少,对症处理后均缓解。结论哌拉西林/他唑巴坦7.5g分别1次/8h或1次/12h静脉滴注治疗老年HAP均有良好疗效和安全性,而1次/8h给药可能更加有效。
Objective To compare the clinical effects and safety of different intermittent intravenous infusion of piperacillin / tazobactam in the treatment of elderly hospital acquired pneumonia (HAP). Methods The elderly HAP patients were randomly divided into two groups. The control group received piperacillin / tazobactam 2.5g once / 8h. The test group received piperacillin / tazobactam 3.75g once / 12h, 100ml saline intravenous infusion, treatment are 10 ~ 14d. Results The clinical cure rate, total effective rate and bacterial clearance rate were 51.43%, 82.86%, 80.00% and 52.78%, 83.33% and 80.56% respectively in the test group and the control group. The incidence rates of drug-related adverse reactions were 8.57% and 8.33% , No significant difference between the two groups; adverse reactions are mainly mild gastrointestinal discomfort, liver dysfunction and leukopenia, symptomatic treatment were relieved. Conclusions Piperacillin / tazobactam 7.5g was effective and safe in the treatment of elderly HAP with either 1 / 8h or 1 / 12h intravenous infusion, respectively. However, once / 8h administration may be more effective.