论文部分内容阅读
近年来,对多形性胶质母细胞瘤(GBM)最常用的治疗方法是立体定向放射外科(SRS)和近距离治疗(BT)。作者对1985.12～1993.7间收治的118例经SRS及BT治疗的复发性GBM病人进行了回顾性研究,并比较了两种疗法的效果。 病人及方法:118例诊断明确的复发性GBM中,86例行SRS治疗,32例行BT~(125)Ⅰ植入疗法。两组病人的肿瘤体积分别平均为10.1cm~3和29cm~3。病人治疗前均接受了外照射。SRS组有28例(33％),BT组有2例(6％)曾接受了化疗。BT组有7例曾接受放射增敏剂(SR2508)。SRS组8例因复发又接受~(125)Ⅰ植入治疗。BT组的病例在局麻下经立体定向引导向瘤体内值入~(125)Ⅰ放射源,平均给予剂量为43CGy/h(34～100cGy/h),治疗平均剂量为50Gy(38.7～63.6Gy),平均作用时间为119h(50～
In recent years, the most commonly used treatments for glioblastoma multiforme (GBM) are stereotactic radiosurgery (SRS) and brachytherapy (BT). The authors retrospectively reviewed 118 patients with recurrent GBM treated with SRS and BT between 1985.12 and 1993.7 and compared the efficacy of the two therapies. Patients and Methods: Among 118 patients with recurrent GBM with definite diagnosis, 86 were treated with SRS and 32 with BT ~ (125) Ⅰ implantation. The tumor volume of two groups of patients averaged 10.1cm ~ 3 and 29cm ~ 3 respectively. Patients received external irradiation before treatment. 28 (33%) patients in the SRS group and 2 patients (6%) in the BT group received chemotherapy. Seven patients in the BT group had received radiosensitizer (SR2508). In the SRS group, 8 patients were relapsed and received ~ (125) Ⅰ implantation. Patients in BT group underwent local stereotactic guidance of ~ (125) Ⅰ radioactive sources into the tumor with the average dose of 43CGy / h (34 ~ 100cGy / h) and mean dose of 50Gy (38.7 ~ 63.6Gy ), The average duration of 119h (50 ~