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在慢性心力衰竭患者中,射血分数保留性心力衰竭(HFp EF)所占的比例越来越大,国外流行病学调查显示HFp EF约占慢性心力衰竭患者的40%~71%,平均为56%,且发病率还在不断的增长,近年来发现HFp EF更多参与左心疾病相关肺高压发病。年龄,高血压,肥胖及冠心病等是HFp EF-PH的高危因素,其中高血压是其主要可控危险因素,鸟苷酸环化酶激动剂,磷酸二酯酶5抑制剂及内皮素受体阻滞剂对于治疗HFp EF-PH治疗并没确切效果,需更进一步研究,但密切关注及控制危险因素是可以提供临床收益。
In patients with chronic heart failure, ejection fractional retention heart failure (HFp EF) is an increasing proportion of foreign epidemiological survey showed HFp EF about 40% to 71% of patients with chronic heart failure, with an average of 56%, and the incidence is still growing, in recent years found that HFp EF more involved in left heart disease-related pulmonary hypertension. Age, hypertension, obesity and coronary heart disease are the risk factors for HFp EF-PH. Hypertension is the main controllable risk factor. Guanylate cyclase agonists, phosphodiesterase 5 inhibitors and endothelin Further studies are needed to determine the effect of blockers on the treatment of HFp EF-PH, but close attention to and control of risk factors may provide clinical benefit.