氨苄西林、羧苄西林的应用使青霉素的抗菌谱已扩大了包括革蓝氏阴性杆菌,临床使用已证明这二药的疗效,但药菌谱窄及随着高剂量的使用而出现毒副反应而限制了它们的使用。临床上虽有一定数量的新青霉素在使用,仍需要有抗菌谱广,特别对绿浓杆菌有作用的新青霉素,阿洛西林是具有这一特点的新青霉素,国产阿洛西林已由四川抗菌素工业研究所研制成功。本文报道国产阿洛西林对临床分离的14种172株革蓝氏阳性、阴性菌的体外抗菌作用,并与其它青霉素类抗生素进行比较。实验结果表明新的脲基青霉素——阿洛西林为一广谱抗生素。在12.5μg/ml时,阿洛西林能抑制85％金黄色 Ampicillin, carbenicillin antibacterial spectrum of penicillin antibacterial spectrum has been expanded, including gram-negative bacilli, clinical use has proved the efficacy of these two drugs, but the drug spectrum is narrow and with the use of high doses of toxic side effects Which limits their use. Although a certain number of clinically new penicillin in use, there is still a need for broad antibacterial spectrum, especially against Pseudomonas aeruginosa new penicillin, azlocillin is a new penicillin with this feature, the domestic azlocillin by Sichuan antibiotics Industrial Institute successfully developed. This article reports the in vitro antibacterial activity of domestic azlocillin against 14 kinds of 172 Gram-positive and -negative bacteria isolated from clinic and compared with other penicillin antibiotics. The experimental results show that the new urea penicillin - azlocillin is a broad-spectrum antibiotics. At 12.5 μg / ml, azlocillin was able to inhibit 85% golden yellow