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甲状腺素(下简称T_4)是甲状腺合成的氨基酸激素。甲状腺分泌T_4后,进入血液循环中,并与蛋白结合。T_4可与TBG(甲状腺结合球蛋白),TBPA(甲状腺结合前清蛋白)和白蛋白等结合。T_4与TBG结合最牢固,与TBPA的亲和力次之,与白蛋白结合最弱。甲状腺所产生的激素约90%都是T_4。因此,测定血清中T_4的含量可较精确地反映甲状腺功能。 1964年Murphy①介绍了利用T_4结合球蛋白(TBG)的特殊亲和力的特性测定了血清
Thyroxine (hereinafter referred to as T_4) is a thyroid synthesis of amino acid hormones. Thyroid secretion T_4, into the blood circulation, and protein binding. T_4 with TBG (thyroid binding globulin), TBPA (pre-thyroglobulin albumin) and albumin and so on. T_4 and TBG binding the most solid, followed by the affinity of TBPA, the weakest albumin binding. About 90% of the hormones produced by the thyroid are T_4. Therefore, the determination of serum T_4 content can more accurately reflect thyroid function. 1964 Murphy introduced the use of T_4 binding globulin (TBG) the characteristics of the special affinity of the serum