硝苯吡啶(心痛定),系一种具有强烈血管扩张作用的钙拮抗剂,对心绞痛、慢性心衰和高血压的治疗特别有效。据报告,副作用发生率低。然而,最近有两个报告,注意到其可以引起肺水肿和严重低血压。作者最近观察到两例病人,于用硝苯吡啶后几小时发生脑缺血。此两例,一例是72岁身性病人,于住院前三天做心电图,因发现有心房纤颤、异位性多发室性期前收缩、不完全性左束支阻滞、左室肥厚和心内膜下缺血征,而用硝苯吡啶1O毫克,日三次,双氢克尿噻50毫克和氨氯吡咪(Amilor Nifedipine (nifedipine), a calcium antagonist with a strong vasodilator effect, is particularly effective in the treatment of angina, chronic heart failure and hypertension. It is reported that the incidence of side effects is low. However, there are two recent reports noting that they can cause pulmonary edema and severe hypotension. The authors recently observed two patients who developed cerebral ischemia hours after being nifedipine. The two cases, an example is a 72-year-old patient with body disease, three days before admission to do ECG, found to have atrial fibrillation, multiple atopic premenstrual contraction, incomplete left bundle branch block, left ventricular hypertrophy and Subendocardial ischemia sign, and with nifedipine 1O mg, three times a day, hydrochlorothiazide 50 mg and amiloride (Amilor