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目的 :了解我国西南地区 1988 1992年非综合征性总唇裂的发生状况及特点。方法 :在 1988 1992年期间 ,采用以医院为单位的整群抽样方法 ,对全国 5 0 0多所医院孕 2 8周至产后 7天的围产儿及非综合征性总唇裂病例进行回顾性分析。结果 :本文报告 1988 1992年西南地区非综合征性总唇裂发生率为 13 8/万 ,其中唇裂为 4.5 /万 ,唇裂合并腭裂为 9.3/万。西藏自治区的非综合征性总唇裂发生率最高 ,分别为 16 .7/万、7.6 /万 ;贵州省以唇合并腭裂最高 ,为 10 .4/万。城乡无显著性差异。男性发生率为 16 .1/万 ,女性为 11.3/万 ,性别比为 1.5 :1。唇裂合并腭裂占总病例的 6 7%。单侧病例占 70 % ,左侧总唇裂为 46 %。结论 :西南地区各省、自治区的非综合征性唇裂发生率存在差异 ,西藏最高 ,四川最低。发生率无变化趋势 ,城乡无差异 ,男性较女性易感。非综合征性唇裂合并腭裂较多发 ,单侧多于双侧 ,以左侧为主。
Objective: To understand the occurrence and characteristics of nonsyndromic general cleft lip in Southwest China in 1988 1992. Methods: During 1988 and 1992, a cluster sampling method using hospitals was used to retrospectively analyze the cases of perinatal and non-syndromic general cleft lip in more than 500 hospitals from 28 weeks to 7 days after birth. RESULTS: This article reported that the incidence of non-syndromic total cleft lip in the southwest region in 1988 was 138/10,000, of which the cleft lip was 4.5/10,000 and the cleft lip/cleft was 9.3/10,000. The incidence of non-syndromic total cleft lip in the Tibet Autonomous Region was the highest, which was 16.7/10,000 and 7.6/10,000, respectively, and the highest in Guizhou Province was 104.4/10,000. There is no significant difference between urban and rural areas. The incidence of males was 16 1/10,000 and that of females was 11.3/10,000, with a sex ratio of 1.5:1. Cleft lip and cleft palate accounted for 6.7 percent of the total cases. Unilateral cases accounted for 70% and left total cleft lip was 46%. Conclusion: There are differences in the incidence of non-syndromic cleft lip in provinces and autonomous regions in the southwestern region, with the highest in Tibet and the lowest in Sichuan. There was no change in the incidence rate, there was no difference between urban and rural areas, and men were more susceptible than women. Non-syndromic cleft lip with cleft palate more frequent, unilateral than bilateral, mainly to the left.