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【目的】探讨人组蛋白脱乙酰化酶2（HDAC2）、白介素1β（IL‐1β）与一氧化氮（NO ）在骨性关节炎发病中的生物学作用。【方法】应用ELISA方法测定HDAC2、IL‐1β以及应用硝酸还原法测定NO在51例骨性关节炎患者（试验组）关节滑液中的含量，并与26例正常人（对照组）进行比较，同时分析 HDAC2和IL‐1β及HDAC2和NO在膝骨性关节炎关节滑液中的相关性。【结果】试验组HDAC2、IL‐1β和NO三个指标在骨性关节炎关节滑液中表达较对照组的关节滑液中的表达明显增高，且差异均有显著性（P＜0．01）。对HDAC2与IL‐1β和NO的水平作Spearman相关分析均呈正相关（相关系数分别为 r＝08．72、08．24，均 P＜00．1）。【结论】HDAC2可能是炎症因子IL‐1β和NO的趋化因子，其可能与促进骨性关节炎的局部非感染性炎症形成有关。“,”[Objective]To investigate the possible biological roles of HDAC2 ,IL‐1β,and NO in the patho‐genesis of osteoarthritis ,and to understand the possible correlation of HDAC2 with IL‐1β,and NO with HDAC2 .[Methods] ELISA was used to determine the amount of HDAC2 and IL‐1 beta ,and the method of nitrate reduction was detected the amount of NO in the synovial fluid of 51 patients with osteoarthritis (obser‐vation group) .The results were compared with corresponding levels of HDAC2 ,IL‐1 ,and NO in 26 normal patients (control group) .In addition ,the relationships of HDAC2 with IL‐1 beta and HDAC2 with NO were explored .[Results]The levels of HDAC2 ,IL‐1 ,and NO in the synovial fluids of the patients were higher in the experimental (observation) group than in the control group ,with the differences beingstatistically signifi‐cant ( P <0 0.1) .Using Spearman correlation analysis ,it was found that for HDAC2 with IL‐1 beta and NO , the correlation coefficients were r=0 8.72 and 0 .824 ,respectively ( P <0 0.1);all indicators were positively correlated .[Conclusion]HDAC2 may be a chemokine of inflammatory cytokines IL‐1 and NO ,which can pro‐mote the formation of local non‐infective inflammation of osteoarthritis .