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目的探讨检测T2DM患者血浆可溶性血栓调节蛋白(sTM)和D-二聚体(D-dimer)水平的临床意义。方法将41例进行冠状动脉造影的T2DM患者分为无冠脉病变(A,n=10)组和有冠脉病变(B,n=31)组。另选取体检健康者19名作为对照(NC)组。Gensini评分系统进行冠脉病变严重程度的评价,测定血浆sTM水平和D-dimer水平。结果与NC组比较,A、B组sTM和D-dimer水平升高(P<0.05);B组高于A组(P<0.05)。Spearman相关分析示sTM和D-dimer均与Gensini积分有相关性(r=0.277,P<0.01;r=0.393,P<0.01)。有序结果的累积比数Logistic回归示D-dimer的OR值为2.14(Z=2.86,P=0.004),sTM的OR值为1.88(Z=2.06,P=0.043)。结论 T2DM患者体内血浆sTM和D-dimer的表达升高,且与T2DM患者的大血管病变呈正相关。
Objective To investigate the clinical significance of detecting plasma soluble thrombomodulin (sTM) and D-dimer in patients with T2DM. Methods 41 patients with T2DM undergoing coronary angiography were divided into two groups: coronary artery disease (A, n = 10) and coronary artery disease (B, n = 31). Another 19 healthy people were selected as control (NC) group. The Gensini score system was used to assess the severity of coronary lesions and to determine plasma sTM levels and D-dimer levels. Results Compared with NC group, the levels of sTM and D-dimer in group A and group B were significantly increased (P <0.05), those in group B were higher than those in group A (P <0.05). Spearman correlation analysis showed that both sTM and D-dimer were correlated with Gensini score (r = 0.277, P <0.01; r = 0.393, P <0.01). Logistic regression showed that the OR of D-dimer was 2.14 (Z = 2.86, P = 0.004). The OR of sTM was 1.88 (Z = 2.06, P = 0.043). Conclusion The expression of plasma sTM and D-dimer in T2DM patients is increased, which is positively correlated with macrovascular disease in T2DM patients.