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手性系一种结构特性,它引起分子不对称,因而与它的镜像互不重叠。最常见的不对称是一个碳原子连有四个不同的功能基团。分子的其它方面都相同,这样一对异构体或对映体用一般物理方法例如熔点和脂溶性并不能区别。如不考虑药物所处的生物环境(即人体)自身具有手性,则这个差别对药理作用没有多大关系。就像一只右手能区别另一只右手和左手,生物大分子也能辨别这一对药物对映体。一对对映体药动学和药效学的明显对映选择性差异常可反映出这一点。
Chirality is a structural property that causes the molecule to be asymmetric and therefore not overlapped with its mirror image. The most common asymmetry is a carbon atom with four different functional groups. The other aspects of the molecule are the same so that the pair of isomers or enantiomers are indistinguishable by general physical methods such as melting point and lipophilicity. Without regard to the biological environment in which the drug is located (ie, the human body) itself has chirality, this difference has little to do with pharmacological effects. Like a right hand can distinguish the other right hand and left hand, biological macromolecules can also distinguish the pair of drug enantiomers. The obvious enantioselectivity difference between a pair of enantiomer pharmacokinetics and pharmacodynamics often reflects this.