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研究了单独给铅和联合给铅锌、铅锌硒对小鼠神经行为功能和脑组织、红细胞脂质过氧化（ＬＰＯ）水平及全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性的相互关系。结果表明单独给铅组小鼠学习记忆能力下降，脑组织和红细胞丙二醛（ＭＤＡ）含量升高，全血ＧＳＨ－Ｐｘ活性降低，与对照组比较具有显著性差异。联合给予铅锌和铅锌硒组水迷宫无误率升高，到达安全台时间缩短，脑组织和红细胞ＭＤＡ含量减少，全血ＧＳＨ－Ｐｘ活性升高，与单独给铅组比较具有统计学意义
The effects of lead and zinc, lead, zinc and selenium on neurobehavioral function, brain tissue, LPO level and GSH-Px activity in mice were studied. The relationship between. The results showed that the learning and memory abilities of the mice in lead alone group were decreased, the content of malondialdehyde (MDA) in brain tissue and erythrocytes increased, and the activity of GSH-Px in whole blood decreased, which was significantly different from the control group. The combination of Pb, Zn and Pb, Zn, Zn and Se groups increased the error rate of water maze, shortened the time to reach the safety table, decreased the content of MDA in brain tissue and erythrocytes, and increased the activity of GSH-Px in whole blood, which was statistically significant compared with lead alone