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目的探讨肝功能衰竭患者医院感染的特点。方法回顾性分析137例肝功能衰竭患者医院感染率、常见感染部位和常见菌株及其构成,感染与肝功能的关系及其对预后的影响。结果 137例肝功能衰竭患者发生医院内感染79例,感染率57.7%;常见感染部位依次为腹腔(22.9%)、胆管系统(22.3%)和胃肠道(17.5%);常见致病菌为大肠埃希氏菌(23.8%)、肺炎克雷伯菌(16.7%)、洋葱伯克霍尔德菌(11.9%);感染者较非感染者血清总胆红素高、凝血酶原活动度低,病死率高(P<0.05)。结论肝功能衰竭患者医院感染率高,以腹腔和大肠埃希氏菌感染多见,与肝功能有关并影响其预后。
Objective To investigate the characteristics of nosocomial infection in patients with liver failure. Methods A retrospective analysis of 137 cases of liver failure patients with nosocomial infection rate, common infection sites and common strains and their composition, the relationship between infection and liver function and its prognosis. Results Among the 137 patients with liver failure, 79 cases were found nosocomial infection, the infection rate was 57.7%. The common infection sites were abdominal cavity (22.9%), bile duct system (22.3%) and gastrointestinal tract (17.5%). Escherichia coli (23.8%), Klebsiella pneumoniae (16.7%) and Burkholderia cepacia (11.9%). Compared with non-infected subjects, serum total bilirubin was higher in patients with infection and the activity of prothrombin Low, high mortality (P <0.05). Conclusions Patients with hepatic failure have a high prevalence of nosocomial infection, more common in abdominal cavity and Escherichia coli, and are associated with liver function and prognosis.