骨肉瘤是儿童青少年中最常见的原发骨恶性肿瘤,发病率约为每年2/100 000~3/100 000,占原发恶性骨肿瘤的20%~([1])。在>65岁的患者中,骨肉瘤多为继发的恶性肿瘤,常与骨Pagets病相关~([2])。骨肉瘤好发于膝关节周围,尤其是股骨远端和胫骨近端的干骺端~([3])。疼痛和局部肿胀是骨肉瘤最常见的早期症状,早期疼痛通常是间歇性的不连续疼痛,容易与生长痛相混淆。血运转移是骨肉瘤转移的主要方式,转移好发部位是 Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. The incidence of osteosarcoma is about 2/100 000 ~ 3 000 000 per year, accounting for about 20% of primary malignant bone tumors [1]. Osteosarcomas are mostly secondary malignancies in patients> 65 years old and are often associated with bone Pagets disease (2). Osteosarcomas occur around the knee, especially in the metaphysis of the distal femur and proximal tibia (3). Pain and local swelling are the most common early signs of osteosarcoma. Early-stage pain is usually intermittent, discontinuous and easily confused with growth pain. Hematogenous metastasis is the main method of osteosarcoma metastasis, the transfer of a good site is