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目的探讨头孢吡肟在胰腺外科中预防和治疗感染的效果。方法收集从2004年10月至2005年2月各类胰腺疾病手术患者20例,在静脉应用头孢吡肟后,测定血清、胰腺组织和胰液中头孢吡肟浓度。结果头孢吡肟在血清中的平均浓度为(2.23±0.24)μg/ml(0.23~4.66μg/ml),胰液中的平均浓度为(6.52±2.07)μg/ml,胰腺组织中的平均浓度为(10.93±1.52)μg/g;头孢吡肟在胰液中的浓度要高于血清中浓度(6.52μg/ml vs 2.23μg/ml,P=0.046)。头孢吡肟在各种胰腺疾病之间的血清中浓度无差异(P>0.05),但在慢性胰腺炎患者中头孢吡肟在胰液和胰腺组织中的浓度要大于其他疾病患者(P<0.05)。结论头孢吡肟能有效地通过血胰屏障,对于胰腺疾病和胰腺手术患者可起到良好的预防和治疗感染效果。
Objective To investigate the efficacy of cefepime in the prevention and treatment of infections in pancreatic surgery. Methods Twenty patients undergoing all kinds of pancreatic diseases from October 2004 to February 2005 were collected. After cefepime was administered intravenously, the concentrations of cefepime in serum, pancreatic tissue and pancreatic juice were measured. Results The average concentration of cefepime in the serum was (2.23 ± 0.24) μg / ml (0.23 ~ 4.66 μg / ml) and the average concentration of pancreatic juice was (6.52 ± 2.07) μg / ml. (10.93 ± 1.52) μg / g. The concentration of cefepime in the pancreatic juice was higher than that in serum (6.52μg / ml vs 2.23μg / ml, P = 0.046). The concentration of cefepime in all kinds of pancreatic diseases had no significant difference (P> 0.05), but in patients with chronic pancreatitis, the concentrations of cefepime in pancreatic juice and pancreas were higher than those in other diseases (P <0.05) . Conclusions Cefepime can effectively cross the blood-pancreas barrier and can prevent and treat infections in patients with pancreatic diseases and pancreatic surgery.