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To evaluate the role about prevention of shunt stenosis after transjugular intrahepatic portosystemic stent shunt (TIPSS) by 103pd stents, 103pd stents and general stents are placed respectively in 18 healthy swines after TIPSS.Angiography, pathological dissection and inspection of lumen area by light microscope are made respectively in the two groups at 4 and 8 weeks after TIPSS. Portal angiography showed that stenosis occured in 2 cases of the radiation group and 3 cases in the control group at 4 weeks. Occlusion was found in all of the radiation group and part stenosis appeared in 2 cases of the radiation group and 3 cases in control group at 4 weeks. Occlusion existed in all of the radiation group and part stenosis appeared in the control group at 8 weeks. Thickness of vascular wall of hepatic vein segment in scope of stents is (3.64±1.01) mm for the radiation group (12.95MBq) and (2.24±1.02) mm for the control group. Difference between two groups is evidenced (p＜0.05). 9.25～12.95MBq 103pd stents can not prevent stenosis after TIPSS.