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有极少的病例使用氯霉素眼药水或氯霉素眼膏导致危及生命的血液病。已有十例以上的严重的可逆性血液病患者,包括再生障碍性贫血,可追溯到曾使用氯霉素眼药史。骨髓抑制症状在连续或频繁间断地使用氯霉素眼药治疗1—23个月以后表现出来。最近在荷兰发生了两例病人。其中一例是角膜糜烂的病人,用氯霉素眼膏治疗一年半,出现血小板减少症,并引起死亡。另一例是白内障手术的病人,在间断使用氯霉素眼药水两年以后,出现再生障碍性贫血,这例患者在停止使用氯霉素治疗后,骨髓造血功能慢慢地恢复正常。
There are very few cases of chloramphenicol eye drops or chloramphenicol ointment leading to life-threatening blood diseases. More than ten patients with severe reversible hematologic disorders, including aplastic anemia, have been traced back to the history of ophthalmic use of chloramphenicol. The symptoms of myelosuppression appear after 1-23 months of continuous or frequent intermittent use of chloramphenicol eyedrops. Two patients have recently occurred in the Netherlands. One case is corneal erosion of patients with chloramphenicol ointment for a year and a half, thrombocytopenia, and cause death. Another case of cataract surgery in patients with intermittent use of chloramphenicol eye drops two years later, there was aplastic anemia, this patient stopped using chloramphenicol treatment, bone marrow hematopoietic function slowly returned to normal.