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目的:观察保肝解毒汤联合西药治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效。方法:将72例ICP患者随机分为观察组35例与对照组37例。对照组给予常规西医治疗,观察组在对照组治疗基础上给予保肝解毒汤治疗,观察2组治疗前后静脉血及脐静脉血肿瘤坏死因子-α(TNF-α)水平的改变情况,对比临床疗效与治疗前后的皮肤瘙痒程度评分。结果:临床疗效总有效率对照组为72.97%,低于观察组的97.14%,差异有统计学意义(P<0.01)。治疗后,2组静脉血及脐静脉血TNF-α水平与治疗前比较,差异均有统计学意义(P<0.01),观察组静脉血及脐静脉血TNF-α水平均低于对照组,差异均有统计学意义(P<0.01)。观察组治疗后7天、14天的皮肤瘙痒程度评分均低于对照组,差异均有统计学意义(P<0.01)。结论:采用保肝解毒汤联合西药治疗ICP患者,可有效促进静脉血及脐静脉血TNF-α水平的调整,并提高临床疗效、缓解皮肤瘙痒,具有较高的临床应用价值。
Objective: To observe the clinical efficacy of Baogan Jiedu Decoction combined with western medicine in treatment of intrahepatic cholestasis of pregnancy (ICP). Methods: 72 patients with ICP were randomly divided into observation group 35 cases and control group 37 cases. The control group was given routine Western medical treatment. The observation group was treated with Baogan Jiedu Decoction on the basis of the control group. The changes of tumor necrosis factor-α (TNF-α) in venous blood and umbilical vein blood before and after treatment were observed. Curative effect and the degree of pruritus before and after treatment. Results: The total effective rate of clinical efficacy was 72.97% in the control group, which was lower than 97.14% in the observation group, the difference was statistically significant (P <0.01). After treatment, the levels of TNF-α in venous blood and umbilical venous blood in two groups were significantly different from those before treatment (P <0.01). The levels of TNF-α in venous blood and umbilical venous blood in observation group were lower than those in control group The differences were statistically significant (P <0.01). The scores of skin pruritus in observation group at 7 days and 14 days after treatment were all lower than those in control group, with statistical significance (P <0.01). Conclusion: The treatment of ICP patients with Baogan Jiedu Decoction combined with western medicine can effectively promote the adjustment of TNF-α level in venous blood and umbilical vein, and improve the clinical curative effect and alleviate the pruritus of skin with high clinical value.