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目的 :通过对胸水多项肿瘤标志物联合检测来鉴别癌性与结核性胸水 ,以提高癌性胸水诊断的阳性率。方法 :用放射免疫分析和化学发光法测定 6 9例 (男 4 7,女 2 2 )结核性胸水、10 7例 (男 83,女 2 4 )癌性胸水CEA、CYFRA2 1- 1、NSE、SF水平 ,两组间进行比较。结果 :癌性胸水组四项肿瘤标志物均值及阳性率均显著高于结核性胸水组 (p均 <0 0 1)。四项指标联检对癌性胸水诊断的阳性率为 95 33%。结论 :胸水CEA、CYFRA2 1- 1、NSE、SF水平检测对鉴别癌性胸水与结核性胸水有重要价值 ,四项指标联合检测可显著提高癌性胸水的阳性诊断率。
OBJECTIVE: To identify the cancerous and tuberculous pleural effusion through the joint detection of a number of tumor markers in pleural effusion to improve the positive rate of diagnosis of cancerous pleural effusion. Methods: Radioimmunoassay and chemiluminescence were used to detect CEA, CYFRA2 1 - 1, NSE in 107 cases (male 83, female 24) of tuberculous pleural effusion in 69 (male 47, female 22) SF levels were compared between the two groups. Results: The mean and positive rates of four tumor markers in cancerous pleural effusion group were significantly higher than those in tuberculous pleural effusion group (all p <0.01). The four indicators of joint detection of cancerous pleural effusion positive rate was 9533%. Conclusion: The detection of CEA, CYFRA2 1- 1, NSE, SF in pleural effusion has important value in differentiating malignant pleural effusion from tuberculous pleural effusion. The combined detection of four indexes can significantly improve the positive diagnostic rate of cancerous pleural effusion.