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目的探讨纳洛酮、氨茶碱联合应用救治重度新生儿窒息的疗效。方法对43例1minApgar评分≤3分的重度窒息新生儿随机分成二组。治疗组22例,复苏时,在常规抢救的基础上使用大剂量纳洛酮每次0.1mg/kg,小剂量氨茶碱每次3mg/kg,脐静脉推注。对照组21例采用新生儿窒息的常规抢救方法,使用洛贝林、可拉明、肾上腺素等药物。对二组病例5、10、15min进行Apgar评分评估。同时对43例患儿进行随访2年,对其后遗症发生率进行比较。结果治疗组5、10、15minApgar评分高于对照组,P值均<0.05,治疗组后遗症发生率明显低于对照组,P<0.05。结论 纳洛酮、氨茶碱联合应用,有利于新生儿窒息的复苏,减少对窒息新生儿心、脑、肺等重要脏器的损害,降低后遗症的发生率。
Objective To investigate the curative effect of naloxone combined with aminophylline in the treatment of severe neonatal asphyxia. Methods Forty-three neonates with severe asphyxia who had 1-minute Anggar score ≤3 were randomly divided into two groups. Treatment group, 22 cases of recovery, the conventional rescue based on the use of large doses of naloxone 0.1mg / kg, a small dose of aminophylline each 3mg / kg, umbilical vein injection. Control group, 21 cases of neonatal asphyxia conventional rescue methods, the use of Lobeline, Clarine, adrenaline and other drugs. Apgar scores were evaluated at 5, 10 and 15 minutes in two groups. At the same time 43 cases of children were followed up for 2 years, the incidence of sequelae were compared. Results The scores of Apgar at 5, 10 and 15min in treatment group were higher than those in control group (P <0.05). The incidence of sequelae in treatment group was significantly lower than that of control group (P <0.05). Conclusion The combination of naloxone and aminophylline is beneficial to the resuscitation of neonatal asphyxia, reducing the damage to vital organs such as heart, brain and lung in neonates with asphyxia, and reducing the incidence of sequelae.