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目的分析宫颈癌盆腔淋巴结转移的危险因素。方法回顾性分析经手术组织病理证实的316例宫颈癌患者临床资料。结果 81例患者发生盆腔淋巴结转移,发生率为25.63%;年龄<40岁,临床分期Ⅱ期、腺癌、肌层浸润深度≥1/2、有脉管侵犯、分化程度3级者淋巴结转移发生率高于年龄≥40岁,临床分期Ⅰ期、鳞癌、肌层浸润深度<1/2、无脉管侵犯、分化程度1,2级者;Logistic多因素回归分析显示,临床分期(OR=2.057)、肌层浸润深度(OR=2.289)及分化程度(OR=4.334,OR=13.500)是淋巴结转移的独立危险因素。结论宫颈癌发生盆腔淋巴结转移与临床分期、肌层浸润深度及细胞分化程度有相关性,对制订治疗方案有指导意义。
Objective To analyze the risk factors of pelvic lymph node metastasis in cervical cancer. Methods The clinical data of 316 patients with cervical cancer confirmed by histopathology were analyzed retrospectively. Results 81 cases had pelvic lymph node metastasis with the incidence rate of 25.63%. The age of patients was less than 40 years old. The clinical stage Ⅱ, adenocarcinoma, myometrial invasion depth ≥1 / 2, vascular invasion, grade 3 lymph node metastasis Logistic regression analysis showed that the clinical stage (OR = 0.45, P <0.01) was significantly higher than that of the patients who were older than 40 years old, stage Ⅰ, squamous cell carcinoma, myometrial invasion depth was less than 1/2, 2.057). The depth of myometrial invasion (OR = 2.289) and the degree of differentiation (OR = 4.334, OR = 13.500) were independent risk factors for lymph node metastasis. Conclusions The occurrence of pelvic lymph node metastasis in cervical cancer is correlated with clinical stage, depth of myometrial invasion and degree of cell differentiation. It is instructive to make treatment plan.