本研究选择急性缺血性脑卒中患者38例,随机分成三组,分别给予尼莫地平、阿斯匹林以及两药伍用治疗,于治疗前、后观察血小板胞浆游离钙浓度和血浆TXB_2含量的变化,结果提示:尼莫地平能阻滞Ca~(++)内流,抑制膜磷脂降解,减少TXA_2的合成,与阿斯匹林伍用效果更佳。作者结合文献探讨了抗钙和抗TXA_2治疗的生化学基础及临床意义,提出治疗脑缺血需联合用药,在多个环节,多种途径上对神经元进行保护。 In this study, 38 patients with acute ischemic stroke were randomly divided into three groups were given nimodipine, aspirin and two drug treatment, before and after treatment of platelet cytoplasmic free calcium concentration and plasma TXB 2 The results suggest that Nimodipine can block Ca ~ (++) influx, inhibit the degradation of membrane phospholipids and reduce TXA_2 synthesis, which is more effective than aspirin. The authors discussed the biochemical basis and clinical significance of anti-calcium and anti-TXA2 therapy combined with the literature, put forward the need for combination therapy for the treatment of cerebral ischemia, in several ways, a variety of ways to protect neurons.