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检测45例病毒性肝炎患者血浆LPO,VitE及红细胞SOD水平,发现急性肝炎组、慢活肝组、重症肝炎组及肝硬化组血浆LPO值分别为5.52±2.6、9.67±5.11、18.22±6.81和7.51±5.051mmol/L.均明显高于正常对照组2.77±0.67(P<0.05),重症肝炎组升高最明显。血浆VitE值分别为9.22±3.83、7.81±2.67、6.56±2.64和6.99±2.67μmol/L,均明显低于正常对照组13.95±4.80(P<0.001),重症肝炎组下降最明显。4种肝病红细胞SOD水平与正常对照组比较无明显改变(P>0.05)。LPO增多、VitE减少与肝功能损伤程度一致。
The levels of plasma LPO, VitE and erythrocyte SOD in 45 patients with viral hepatitis were detected. The values of LPO in acute hepatitis group, chronic active hepatitis group, severe hepatitis group and cirrhosis group were 5.52 ± 2.6,9.67 ± 5.11,18.22 ± 6.81 and 7.51 ± 5.051mmol / L were significantly higher than the normal control group 2.77 ± 0.67 (P <0.05), the most significant increase in severe hepatitis group. The plasma VitE values were 9.22 ± 3.83, 7.81 ± 2.67, 6.56 ± 2.64 and 6.99 ± 2.67 μmol / L, respectively, which were significantly lower than those in the control group (13.95 ± 4.80, P <0.001). There was no significant difference in SOD level among the four kinds of liver disease erythrocytes compared with the control group (P> 0.05). LPO increased, decreased VitE and liver damage consistent.