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目的:探讨转化生长因子-β1(TGF-β1)在宫颈癌组织中的表达及其临床意义。方法:采用免疫组化SP法检测TGF-β1蛋白在50例宫颈癌、25例宫颈上皮内瘤样病变(CIN)和25例正常宫颈组织中的表达情况。结果:TGF-β1蛋白在宫颈癌组、CIN组和正常宫颈组中的阳性表达率分别为86%、44%、12%。宫颈癌组与CIN组、正常宫颈组比较差异均有统计学意义(P<0.01),CIN组与正常宫颈组比较差异有统计学意义(P<0.05)。结论:TGF-β1与宫颈癌发生有关,为宫颈癌的治疗提供一种新的潜在的靶分子。
Objective: To investigate the expression of transforming growth factor-β1 (TGF-β1) in cervical cancer and its clinical significance. Methods: Immunohistochemical SP method was used to detect the expression of TGF-β1 protein in 50 cases of cervical cancer, 25 cases of cervical intraepithelial neoplasia (CIN) and 25 cases of normal cervical tissue. Results: The positive rates of TGF-β1 protein in cervical cancer group, CIN group and normal cervical group were 86%, 44% and 12% respectively. The difference between cervical cancer group and CIN group and normal cervical group was statistically significant (P <0.01). There was significant difference between CIN group and normal cervical group (P <0.05). Conclusion: TGF-β1 is associated with the development of cervical cancer and provides a new potential target for the treatment of cervical cancer.