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[目的]观察鼻窦内镜术对慢性鼻窦炎伴支气管哮喘患者哮喘发作的影响。[方法]对2007年3月～2009年3月收治的60例慢性鼻窦炎兼哮喘患者施行ESS术,60例患者均于术前、术后采用酶联免疫吸附测定法(ELISA)检测外周血单个核细胞培养上清液中的白细胞介素4(IL-4),干扰素(IFN-γ),EOS。[结果]鼻窦炎合并支气管哮喘患者术前PBMC培养上清液中IL-4降低,而IFN-γ含量较对照组显着升高,EOS降低。[结论]注意这些因子可以为临床提供治疗证据。
[Objective] To observe the effect of endoscopic sinus surgery on asthma attacks in patients with chronic sinusitis and bronchial asthma. [Methods] Sixty patients with chronic sinusitis and asthma admitted to our hospital from March 2007 to March 2009 underwent ESS. All 60 patients underwent ESS before and after surgery, and peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA) Interleukin-4 (IL-4), Interferon (IFN-γ), EOS in Mononuclear Cell Culture Supernatants. [Results] IL-4 in the culture supernatant of patients with sinusitis and bronchial asthma preoperatively decreased, while the content of IFN-γ was significantly higher than that of the control group and the EOS was decreased. [Conclusion] Note that these factors can provide clinical evidence for treatment.