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目的 比较微波消融术与开放手术治疗甲状腺良性结节对机体应激反应的影响.方法 前瞻性选取2016年1月至2016年7月良性甲状腺结节患者108例,随机分成微波组57例和开放组51例,分别行甲状腺结节微波消融术和传统开放性手术.比较两组术前1 d及术后8、24、48 h的体温、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)、皮质醇(COR)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平.结果 术后24 h开放组患者体温高于微波组(P<0.05);术后24、48 h开放组WBC高于微波组(P<0.05);术后8、24、48 h开放组VAS高于微波组(P<0.05);术后8、24、48 h开放组hs-CRP、 IL-6、COR均高于微波组,两组比较差异有统计学意义(P<0.05).结论 微波消融术对机体应激反应的影响明显小于开放手术,显示了微波手术微创的优越性.“,”Objective To compare the effects of systemic stress responses after microwave ablation and traditional open surgery on benign thyroid nodules.Methods A total of 108 patients with benign thyroid nodules from January 2016 to July 2016 were randomly divided into microwave ablation group(57 cases, underwent microwave ablation) or open surgery group(51 cases, underwent traditional open surgery).Blood samples were taken preoperative(baseline), 8 h, 24 h, and 48 h postoperative.Body temperature, white blood cell (WBC) count, plasma levels of cortisol (COR), high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) were measured.Visual analogue scale (VAS) was also recorded after operation.Results Body temperature at 24 hours after operation was higher in open surgery group than that in microwave ablation group (P<0.05).WBC at 24 and 48 hours after operation were higher in open surgery group than those in microwave ablation group (P<0.05).Visual analogue scale at 8, 24 and 48 hours after operation were higher in open surgery group than those in microwave ablation group (P<0.05).The plasma levels of hs-CRP, IL-6 and COR on 8, 24 and 48 hours postoperative were higher in open surgery group than those in microwave ablation group, and the differences were significant (P<0.05).Conclusions There is less systemic stress response after microwave ablation than traditional open surgery for benign thyroid nodules.Microwave ablation for benign thyroid nodules is characterized by minimal invasion.