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目的探讨HBV-DNA水平对HBIG母婴阻断效果的影响,研究提高阻断成功率的有效方法。方法将乙肝携带产妇和婴儿应用HBIG的情况按照HBV-DNA水平分层,分析HBIG不同使用方法和使用时机对阻断成功率的影响。结果儿童出生后乙肝球蛋白注射2针次与1针次的阻断成功率没有差别;HBV-DNA阳性的孕妇产前多次注射乙肝球蛋白可以提高阻断成功率。分娩方式、婴儿喂养方式对阻断成功率没有影响。结论 HBV-DNA阳性孕妇产前注射乙肝球蛋白3针次的阻断效果好,HBV-DNA阴性孕妇产前可以不注射乙肝球蛋白,而只在儿童出生后注射乙肝球蛋白,阻断效果即可达到最佳。自然分娩和母乳喂养对婴儿是安全的,不增加乙肝感染率。儿童出生后乙肝球蛋白注射1针次就可达到效果。
Objective To investigate the effect of HBV-DNA on the blocking effect of HBIG on maternal and infants, and to study the effective ways to improve the success rate of blocking. Methods According to the level of HBV-DNA, HBIG in HBsAg-positive pregnant women and infants were stratified to analyze the influence of HBIG using methods and timing on the success rate of blocking. Results There was no difference in the success rate of the injection of Hepatitis B between the two doses of HepG on the 1st and the 2nd needle after birth. HBV-DNA-positive pregnant women could increase the success rate of blocking the injection of HepG. Mode of delivery, infant feeding has no effect on the success rate of blockage. Conclusion HBV-DNA positive pregnant women prenatal injection of hepatitis B virus 3 needle times good blocking effect, HBV-DNA negative pregnant women prenatal injection of hepatitis B globulin, but only in children after injection of hepatitis B globulin, the blocking effect that Reach the best. Natural childbirth and breastfeeding are safe for infants and do not increase the rate of hepatitis B infection. Children born after hepatitis B hemoglobin injection 1 needle times to achieve the desired effect.