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目的定量分析醋氨酚、布他比妥和咖啡因联用的镇痛作用及急性毒性变化 ,以确定合适的联用比例和联用剂量。方法采用配方均匀设计法设置7个水平联用比例和剂量 ,用小鼠甩尾法作镇痛试验 ,综合数理分析结果和专业知识 ,再经确定性试验证实 ;采用参数法分析联用的急性毒性数据。结果(1)醋氨酚40.7mg/kg,布他比妥6.4mg/kg 和咖啡因5mg/kg联用效果较好 ,其联用比例为8.1∶1.25∶1 ;(2)3药联用有协同作用 ;(3)联用的急性毒性未见增强。结论醋氨酚 ,布他比妥和咖啡因联用(8.1∶1.25∶1)镇痛效应增强 ,但毒性未增(无协同作用)
OBJECTIVE: To quantitatively analyze the analgesic effects and the acute toxicity changes of acetaminophen, bumetanide and caffeine to determine the appropriate combination ratio and combination dose. Methods The formula and method of uniform formulation were used to set the 7 levels of combination ratio and dosage. The mouse tail flick method was used for analgesic test. The results of mathematical analysis and professional knowledge were combined and confirmed by confirmatory test. Toxicity data. Results (1) Acetaminophen 40.7mg / kg, bumetal bupivate 6.4mg / kg and caffeine 5mg / kg combined effect is better, the combined ratio of 8.1: 1.25: 1; (2) There is synergy; (3) combined with the acute toxicity has not been enhanced. Conclusions The combination of acetaminophen, bumetanide and caffeine (8.1: 1.25: 1) enhanced the analgesic effect, but the toxicity was not increased (no synergistic effect)