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应用免疫组织化学方法对４５例原发性脑星形细胞瘤石蜡包埋标本进行ｃ－ｅｒｂＢ－１表达产物表皮生长因子受体（ＣＥＧＦＲ）以及ｃ－ｅｒｂＢ－２表达产物进行检测，结果表明：ＥＧＦＲ以及ｃ－ｅｒｂＢ－２在高级别星形细胞瘤中的表达阳性率（分别为７２％、５６％）均显著高于低级别星形细胞瘤（分别为２５％、１５％，Ｐ＜０．０１），且两者表达呈相关性（Ｐ＜０．０５）。提示ＥＧＦＲ、ｃ－ｅｒｂＢ－２在星形细胞瘤中的表达与肿瘤病理分级有潜在关系，两者的表达不是相互独立的，且ｃ－ｅｒｂＢ－２表达可能仅限于那些有高水平ＥＧＦＲ表达的肿瘤细胞中
Immunohistochemical method was used to detect c-erbB-1 expression products of epidermal growth factor receptor (CEGFR) and c-erbB-2 expression products in 45 paraffin-embedded primary cerebral astrocytoma specimens. The results showed that: The positive rate of EGFR and c-erbB-2 expression in high-grade astrocytomas (72%, 56%, respectively) were significantly higher than those in low-grade astrocytomas (25%, 15%, P<0, respectively). .01), and there was a correlation between the two expressions (P<0.05). It is suggested that the expression of EGFR and c-erbB-2 in astrocytomas has a potential relationship with the pathological grade of tumors. The expression of c-erbB-2 is not independent of each other, and the expression of c-erbB-2 may be limited to those with high levels of EGFR expression. Tumor cells