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应用ELISA双抗体夹心法测定41例胃癌患者血浆D-二聚体水平,结果表明,胃癌组D-二聚体水平明显高于健康对照组和慢性胃炎组(P<0.01),低分化癌明显高于高分化癌(P<0.05),Ⅲ~IV期患者明显高于Ⅰ~Ⅱ期患者(P<0. 05)。15例肿瘤切除后D-二聚体比术前显著降低(P<0.01),术后复发者又复升高。提示动态测定血浆D-二聚体变化对肿瘤患者的病情判断、疗效观察和评估预后具有重要意义。
The plasma D-dimer levels in 41 patients with gastric cancer were measured by ELISA double antibody sandwich method. The results showed that the D-dimer level in gastric cancer group was significantly higher than that in healthy control group and chronic gastritis group (P<0.01), and poorly differentiated cancer was obvious. Higher than well-differentiated carcinoma (P<0.05), patients with stage III-IV were significantly higher than patients with stage I-II (P<0.05). The D-dimer in 15 patients after tumor resection was significantly lower than before surgery (P<0.01), and the recurrence was re-elevated. The dynamic measurement of plasma D-dimer changes is of great significance to the patient’s condition judgment, curative effect observation and prognosis evaluation.