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Objective: To investigate the effect of Epalrestat combined with Huoxue Huayu preparation on early diabetic retinopathy and its effect on serum oxidative stress and inflammatory factors. Methods: 132 patients with early diabetic retinopathy from June 2017 to July 2019 in our hospital were randomly divided into the control group (66 cases) and the observation group (66 cases); The control group was treated with epalrestat, and the observation group was treated with epalrestat combined with ginkgo damo injection; The treatment effect, blood rheology indexes, serum oxidative stress indexes and inflammatory factor indexes of the two groups were compared. Results: The treatment efficiency of the observation group (96.96％) was significantly higher than that of the control group (84.84％) (P <0.05). After 3 months of treatment, the high-cut whole blood viscosity (3.62 ± 0.45 mPa / s), low-cut whole blood viscosity (1.54 ± 0.26 mPa / s), erythrocyte sedimentation rate (15.63 ± 2.97 mm / s) of the observation group compared with the control group (4.57 ± 0.52 mPa / s, 2.91 ± 0.30 mPa / s, 22.36 ± 3.38 mm / s) were significantly lower (P <0.05). After 3 months of treatment, the SOD (93.41 ± 10.17 nmol / mL) and TAC (20.57 ± 3.76 u / mL) of the observation group compared with the control group (82.26 ± 9.45 nmol / mL, 18.26 ± 3.63 u / mL) were significantly higher (P <0.05), and the MDA of the observation group (9.22 ± 1.98 u / mL) was significantly lower than that of the control group (12.13 ± 1.06 u / mL) (P <0.05). After 3 months of treatment, the CRP (9.74 ± 1.12 mg / L), IL-2 (70.37 ± 12.13 ng / L), TNF-a (11.36 ± 2.08 ng / L) of the observation group compared with the control group (15.28 ± 1.73 mg / L L, 82.46 ± 10.58 ng / L, 16.28 ± 2.43 ng / L) were significantly lower (P <0.05). Conclusion: Epalrestat combined with Huoxue Huayu preparation is more effective in the treatment of early diabetic retinopathy, and can significantly improve the blood rheology indexes, serum oxidative stress indexes and inflammatory factor indexes of patients.