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免疫抑制是治疗自身免疫慢性活动性肝炎的有效方法。1968年首次报告用强的松治疗可改善生存,这已在随后的一些对照实验中予以证实。研究还表明,较低剂量的硫唑嘌呤与强的松并用可能抑制此病,而且可通过使用较低剂量的强的松避免皮质酮类药物治疗时引起的令人生厌的副反应。但有些病人对硫唑嘌呤过敏,难以耐受此药,只能单独用强的松控制疾病。不幸的是,一些病人因需大剂量的强的松而产生严重的副反应。 1978年环孢菌素首次用于器官移植,并显示出强大的免疫抑制特性。该药使肝、肾移植患
Immunosuppression is an effective method of treating autoimmune chronic active hepatitis. First reported in 1968 with prednisone treatment can improve survival, which has been confirmed in a number of subsequent control experiments. The study also showed that lower doses of azathioprine in combination with prednisone may inhibit the disease and avoid objectionable side effects caused by the use of lower doses of prednisone when treated with corticosteroids. However, some patients allergic to azathioprine, it is difficult to tolerate this drug, only prednisone alone to control the disease. Unfortunately, some patients develop severe side effects due to high doses of prednisone. Cyclosporine was first used in organ transplants in 1978 and showed strong immunosuppressive properties. The drug causes liver and kidney transplant