胆管癌(cholangiocarcinoma)发展隐蔽,临床症状及体征出现晚,给早期诊断带来困难;若能找到一种敏感性和特异性均较高的肿瘤标志物,将为胆管癌早期诊断带来突破性进展,本文对近年来肿瘤标志物在胆管癌早期诊断中的研究进展做一综述。1蛋白质肿瘤标志物1.1癌胚抗原(carcinoembryo The development of cholangiocarcinoma is hidden, and clinical symptoms and signs appear late, which brings difficulties in early diagnosis. If a tumor marker with higher sensitivity and specificity can be found, it will bring a breakthrough in the early diagnosis of cholangiocarcinoma In this paper, we reviewed the progress of tumor markers in the early diagnosis of cholangiocarcinoma in recent years. 1 Protein Tumor Markers 1.1 Carcinoembryonic Antigen (carcinoembryo