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目的观察三七总皂苷(PNS)对高血压性脑出血(HICH)血肿吸收及神经功能恢复的影响。方法将入选的HICH患者120例随机分为PNS组(常规药物治疗加三七总皂苷)58例和对照组(常规药物治疗)62例;所有入选患者分别于入组第1、4、10、17 d利用CT测量血肿体积,并进行神经功能缺损评分(NIHSS)和日常生活活动能力评定(ADL)。对照组采用内科常规脑出血治疗方法,PNS组先采用常规药物治疗3 d,并于第4 d开始加用血塞通注射液(主要成分为PNS)0.4 g静滴,1次/d,连用14 d,于第10 d和第17 d进行疗效判定。结果 PNS组第10、17 d血肿体积均小于对照组(P<0.01);第10 d神经功能缺损评分低于对照组(P<0.05),第17 d神经功能缺损评分低于对照组(P<0.01),日常生活活动能力分值均高于对照组(P<0.01)。结论三七总皂苷能明显促进高血压性脑出血血肿的吸收,促进神经功能的恢复。
Objective To observe the effect of Panax Notoginseng Saponins (PNS) on the hematoma absorption and neurological function recovery of hypertensive intracerebral hemorrhage (HICH). Methods A total of 120 HICH patients were randomly divided into PNS group (58 cases) and control group (62 cases). All the patients were enrolled in group 1, 4, 10, At 17 days, the volume of hematoma was measured by CT, and neurological deficit score (NIHSS) and daily living activity assessment (ADL) were performed. The patients in the control group were treated with conventional intracerebral hemorrhage. The patients in the PNS group were treated with conventional drugs for 3 days. On the 4th day, they were treated with 0.4 g intravenous injection of Xuesaitong Injection (PNS) once daily for 4 days, On the 14th day, the curative effect was evaluated on the 10th and 17th days. Results The volume of hematoma in the PNS group was lower than that in the control group on the 10th and 17th day (P <0.01). The score of neurological deficit on the 10th day was lower than that of the control group (P <0.05), and the score of neurological deficit on the 17th day was lower than that of the control group <0.01). The scores of activities of daily living were higher than those of the control group (P <0.01). Conclusion Panax notoginseng can obviously promote the absorption of hematoma in hypertensive intracerebral hemorrhage and promote the recovery of neurological function.