氟负离子的碱性行为虽在卅年前就已被认识,但对其本质的深入研究及其在有机合成中的应用却主要是七十年代以后的事。氟负离子的碱性不仅与其抗衡的阳离子、溶剂及体系中水的含量,且也与有无添加冠醚等相转移催化剂有关。氟负离子的碱性行为使其本身或另一化合物具有很好的亲核能力,因而能催化或非催化地促成多种有机反应。 Though the basic behavior of fluorine anion has been known before 1989, the deep research on its essence and its application in organic synthesis mainly took place after the seventies. The basicity of fluoride anion is not only related to the cation, solvent and the water content in the system, but also to the phase transfer catalyst such as the addition of crown ether. The basic behavior of fluoride anion makes it or another compound has a good nucleophilic ability, which can catalyze or non-catalytic to promote a variety of organic reactions.