对157例食管癌病人进行DNA分析,计算出DNA增殖指数,同时采用三种不同的分割照射方法即常规照射、常规+超分割照射、大分割照射,并对二者进行了相关分析。DNA测定采用FACS420流式细胞仪进行检测,标本来源于食管镜活检组织。结果157例食管癌病人的DI平均值为1.50±0.30,其中常规照射组1.41±0.27、常规+超分割组1.57+0.33、大分割组1.53+0.30,并对其即时疗效、一年生存率与DI的关系进行了分析,同时对一年内死亡者与生存一年以上病人的DI进行了比较。结果表明,三组治疗后即时疗效与DI值无关,三组DI>和<1.30者的一年生存率均无差别,从一年内死亡者和生存一年以上者来看,常规照射组和大分割照射组均是一年内死亡者的DI值高于生存一年以上者,而常规+超分割组则相反,生存一年以上者反而比一年内死亡者的DI值高。这就说明单用DI值的高低来评价预后是不够的,必须结合不同的照射方法。针对这个问题,又对三组完全缓解病人的DI值及生存一年以上者的DI值进行了分析,其结果是三组完全缓解病人的DI值无差别,而生存一年以上者的DI值是有明显差别的,即常规+超分割组明显高于常规组及大分割组,常规组与大分割组之间无差别。这也说明了DI值的高低不是预后的关键因素。同时,也对三组一年生存率进行了分析,结果常规+超分割组? DNA analysis was performed on 157 patients with esophageal cancer and the DNA proliferation index was calculated. Three different methods of segmented irradiation were used: conventional irradiation, conventional + hyperfractionated irradiation, and large-segment irradiation, and both were correlated. DNA was measured using the FACS420 flow cytometer and specimens were derived from biopsy tissue from the esophagoscope. Results The average DI of 157 patients with esophageal cancer was 1.50±0.30, including 1.41±0.27 in the conventional irradiation group, 1.57+0.33 in the regular+ultra-segmented group, and 1.53+0.33 in the large-segmented group. The immediate effect and one-year survival rate were comparable. The relationship between DI was analyzed, and at the same time the DI was compared with those who had survived more than one year in one year. The results showed that the immediate effect of the three groups after treatment had nothing to do with the DI value. There was no difference in the one-year survival rate of the three groups DI> and <1.30. From the one-year deaths and survival of more than one year, the conventional irradiation group and large In the segmented irradiation group, the DI value of those who died within a year was higher than those who survived for more than one year, whereas in the conventional + hyperfractionation group, the DI value of those who survived more than one year was higher than those who died within a year. This shows that the use of DI alone to assess the prognosis is not enough, must be combined with different methods of irradiation. In response to this question, the DI values ​​of three groups of complete remission patients and DI values ​​of those who survived for more than one year were analyzed. The result was that the DI values ​​of the three groups of complete remission patients had no difference, and the DI values ​​of those who survived more than one year. There is a significant difference, that is, the conventional + hyperfractionation group is significantly higher than the conventional group and the large segmentation group, there is no difference between the conventional group and the large segmentation group. This also shows that the level of DI is not a key factor in the prognosis. At the same time, the three-year survival rate was also analyzed. The results were routine + hyperfractionated?