目的 :应用恩丹西酮预防小儿氯胺酮麻醉围术期恶心、呕吐的发生率。方法 :随机选择 30例小儿唇裂整形术患儿 ,分为恩丹西酮组 ( 1 5例 )和对照组 ( 1 5例 ) ,全部采用氯胺酮麻醉。氯胺酮给药 1 0min后 ,经静脉缓慢注入恩丹西酮或安慰剂进行双盲法研究 ;结果 :安慰剂组恶心、呕吐发生率为 2 0 %、5 3 33% ;恩丹西酮组恶心、呕吐发生率为 2 6 7%、6 6 7% (P <0 0 5 ) ;结论 :恩丹西酮适用小儿氯胺酮麻醉围术期恶心呕吐的预防 Objective: To prevent the incidence of nausea and vomiting during perioperative anesthesia with pediatric ketamine in ondansetron. Methods: Thirty children with cleft lip were selected randomly, divided into ondansetron group (15 cases) and control group (15 cases), all were anesthetized with ketamine. Ketamine administered 10 min after the slow venous injection of ondansetron or placebo for double-blind study; Results: nausea and vomiting placebo group was 20%, 3333%; Ondansetron group nausea , The incidence of vomiting was 26.7%, 66.7% (P0 05) .Conclusion: Ondansetron is suitable for prophylaxis of perioperative nausea and vomiting during ketamine anesthesia in children