天然产物未知结构的测定,经典的方法主要是通过化学降解。近三十年来,由于新技术与新仪器的出现及其广泛应用,化学方法的比重已逐步下降,目前基本上以仪器分析为主,化学降解已成为辅助手段。可用杜鹃酮(1)的研究过程加以说明。杜鹃酮的羰基位阻较大,在一般条件下不与羰基试剂反应,早期命名为 The determination of the unknown structure of natural products, the classic method is mainly through chemical degradation. In the recent three decades, due to the emergence of new technologies and new instruments and their wide application, the proportion of chemical methods has been gradually declining. At present, the analysis is mainly based on instrumentation, and chemical degradation has become an auxiliary measure. Available rhododendron ketone (1) research process to illustrate. Rhododendron ketone carbonyl steric hindrance, under general conditions does not react with the carbonyl reagent, earlier named