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肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)是主要组织相容性复合体(major histocompatibility complex,MHC)基因编码的同源三聚体蛋白,TNF-α与其受体结合后可发挥免疫调节作用并参与机体的多种病理生理过程,包括发热、炎症、感染、创伤愈合和肿瘤杀伤。TNF-α是炎症通路中一重要的细胞因子,存在于类风湿关节炎(rheumatoid arthritis,RA)患者的滑膜组织、滑液及血清中。TNF-α通过与多种组织因子和基质蛋白相互作用促进RA的炎症反应、滑膜细胞异常增殖和凋亡、血管翳生成及软骨与骨的破坏,推动RA炎症反应持续性进展。因而,TNF-α可以作为RA病情活动的一个临床指标,同时又是治疗RA的一个有效靶点。
Tumor necrosis factor alpha (TNF-α) is a heterotrimeric protein encoded by the major histocompatibility complex (MHC) gene. TNF-α binds to its receptor Immune regulation and participation in the body’s various pathophysiological processes, including fever, inflammation, infection, wound healing and tumor killing. TNF-α is an important cytokine in the inflammatory pathway, which is present in synovial tissue, synovial fluid and serum of patients with rheumatoid arthritis (RA). TNF-α promotes the inflammatory response of RA, the abnormal proliferation and apoptosis of synovial cells, the formation of angiogenesis and the destruction of cartilage and bone through the interaction with various tissue factor and matrix protein, and promotes the continuous progress of RA inflammatory reaction. Thus, TNF-α can be used as a clinical indicator of RA disease activity, but also an effective target for the treatment of RA.