目的分析雌激素在宫腔粘连治疗中相同给药剂量、不同给药方式对血雌二醇浓度的影响。方法观察因闭经或月经量少就诊,行宫腔镜检查诊断为宫腔粘连患者35例。入组患者应用经皮吸收雌激素与口服雌激素各1个周期,分别于月经周期第2天、第5天测血雌二醇浓度,比较两组用药前、用药后血雌二醇浓度的高低。结果经皮雌激素、口服雌激素用药前血雌二醇浓度比较,差异无统计学意义(P>0.05);经皮雌激素治疗期间血雌二醇浓度高于口服用药期间血雌二醇浓度,且差异有统计学意义(P<0.05)。结论经皮雌激素可以更有效升高血雌二醇浓度,且用药安全、方便。 Objective To analyze the effect of estrogen on the concentration of estradiol administered by the same administration dose and administration mode of estrogen in intrauterine adhesions. Methods Observation of amenorrhea or menstruation due to less treatment, hysteroscopy diagnosis of intrauterine adhesions in 35 patients. The patients were divided into two groups: percutaneous absorption of estrogen and oral estrogen by one cycle. The levels of serum estradiol were measured on the second day and the fifth day of the menstrual cycle respectively. Before and after treatment, the serum estradiol concentrations High and low. Results There was no significant difference in serum estradiol concentrations between transdermal estrogen and oral estrogen before treatment (P> 0.05). The blood estradiol concentration during transdermal estrogen treatment was higher than that of oral estradiol during oral administration , And the difference was statistically significant (P <0.05). Conclusion Percutaneous estrogen can increase blood estradiol concentration more effectively and is safe and convenient.