脑膜瘤是中枢神经系统常见肿瘤,多表现为良性,但预后却多样化。为探究不同级别和不同侵袭性脑膜瘤之间的差异性,已对其进行了大量研究。本文就NF2基因、Hedgehog信号通路、Ki-67、E-钙粘蛋白与β-连环蛋白、基质金属蛋白酶与组织抑制因子、尿激酶纤溶酶原激活剂及其抑制剂、骨桥蛋白等研究热点对脑膜瘤侵袭性相关因素进行综述。 Meningioma is a common tumor of the central nervous system, mostly benign, but the prognosis is diversified. To investigate the differences between different grades and different invasive meningiomas, a large number of studies have been conducted. In this paper, NF2 gene, Hedgehog signaling pathway, Ki-67, E-cadherin and β-catenin, matrix metalloproteinases and tissue inhibitors, urokinase plasminogen activator and its inhibitors, such as osteopontin Hot spots on the invasion of meningioma related factors are reviewed.