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目的调查分析南阳市女性HPV感染情况以及分型情况。方法选择在南阳市中心医院进行妇科检查的1893例女性作为研究对象,对宫颈脱落细胞人乳头状瘤病毒(HPV)DNA基因分型进行检测,得出HPV的感染率和HPV分型情况。研究HPV分型与宫颈病变,HPV感染和HPV分型与年龄,HPV感染与怀孕次数、分娩次数以及流产次数之间的关系。结果 1 893例女性中,364例感染HPV,感染率为19.23%。其中HPV单一感染241例,占感染人数的66.21%;HPV双重感染59例,占感染人数的16.21%;HPV三重及以上感染16例,占感染人数的4.39%。HPV分型感染率最高的是HPV 16,其余依次为HPV 58、HPV 33、HPV 18、HPV 52等;HPV 16也是最容易导致宫颈癌前病变及宫颈癌的分型。>45岁和<30岁女性HPV感染率以及高危HPV分型的感染率均高于30~45岁女性,差异有统计学意义(P<0.05)。多次妊娠和多次分娩是HPV感染的危险因素。近50%的HPV感染女性存在外伤史,最常见的是结扎手术。结论南阳市女性HPV感染分型以HPV 16为主,年轻女性、中老年女性、有多次妊娠史和分娩史女性、有外伤史女性感染HPV的几率较高,需加强相关的筛查工作。
Objective To investigate and analyze the status of HPV infection and its classification in women in Nanyang City. Methods A total of 1893 women with gynecological examination in Nanyang Central Hospital were enrolled in this study. Genotypes of cervical exfoliated human papillomavirus (HPV) DNA were detected and HPV infection rate and HPV typing were obtained. To study the relationship between HPV typing and cervical lesions, HPV infection and HPV typing and age, HPV infection and pregnancy frequency, number of deliveries and abortion frequency. Results Among 1 893 women, 364 were infected with HPV, the infection rate was 19.23%. Among them, 241 cases of single HPV infection accounted for 66.21% of the total number of infected persons; 59 cases of double HPV infection accounted for 16.21% of the total number of infected persons; 16 cases of HPV infection of triplet and above accounted for 4.39% of the infected persons. The highest HPV typing rate is HPV16, followed by HPV58, HPV33, HPV18, HPV52, etc .; HPV16 is also the most likely to cause cervical precancerous lesions and cervical cancer typing. The prevalence of HPV infection in 45-year-old and <30-year-old women and high-risk HPV genotypes were higher than those in 30-45-year-old women. The difference was statistically significant (P <0.05). Multiple pregnancies and multiple births are risk factors for HPV infection. Nearly 50% of women with HPV infection have a history of trauma, the most common being ligation. Conclusion HPV infection in women in Nanyang City is mainly HPV16. There are many women with pregnancy and childbirth history. There is a high risk of HPV infection in women with history of trauma. Therefore, relevant screening work should be strengthened.