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目的探讨膀胱内翻性乳头状瘤的临床病理特点、诊断及鉴别诊断。方法回顾我院28例膀胱内翻性乳头状瘤患者的临床资料,结合以往文献资料对膀胱内翻性乳头状瘤的临床特点进行分析,HE染色,光镜观察。结果肉眼观察:肿瘤直径0.5~6cm,平均2.4cm,呈息肉状,有蒂或广基,表面较光滑。镜下观察:28例膀胱内翻性乳头状瘤其基本组织学图像为表面被覆形态正常的移行上皮细胞,增生的上皮细胞向下凹陷呈内生性生长,形成上皮巢状结构,巢中心为平行排列的上皮细胞,周围细胞呈栅栏状排列。瘤细胞卵圆形或梭形,形态规则,大小一致,无异型性,偶见核分裂相。结论膀胱内翻性乳头状瘤是一种少见的预后好、复发少的良性肿瘤,确诊需排除尿路上皮癌、低度恶性潜能的乳头状瘤和腺性囊性膀胱炎。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of inverted papilloma of the bladder. Methods The clinical data of 28 patients with inverted papilloma of the bladder in our hospital were retrospectively analyzed. The clinical features of inverted papilloma of the bladder were analyzed based on previous literatures. HE staining and light microscopy were performed. Results Macroscopic observation: Tumor diameter 0.5 ~ 6cm, an average of 2.4cm, was polypoid, pedunculated or wide base, the surface is relatively smooth. Microscopic observation: 28 cases of inverted papilloma of the basic histological image of the surface of the normal morphology of epithelial cells transitional hyperplasia of epithelial cells downward depression was endogenous growth, the formation of epithelial nests, the center of the nest is parallel Arranged epithelial cells, cells arranged in a fence around. Oval or spindle tumor cells, the shape of the rules, the same size, no atypia, occasional mitotic phase. CONCLUSIONS: Inverted papilloma of the bladder is a rare benign tumor with few recurrences. Urinary tract epithelial carcinoma and low grade malignant papilloma and cystitis cystitis should be excluded.