论文部分内容阅读
目的分析低T_3水平与急性脑梗死临床严重程度及预后的关系。方法选取神经内科病房收治的急性脑梗死患者119例,根据入院时简易精神状态评分量表(MMSE)评分分为轻、中、重组,对比3组游离T_3(FT3)、游离T4(FT4)和促甲状腺激素(TSH)水平。根据T_3水平分为低T_3亚组和T_3正常亚组,比较2组入院时及出院后30 d美国国立卫生研究院卒中量表(NIHSS)和改良Rankin量表(mRS)评分。结果轻组、中组、重组FT3水平比较差异有统计学意义(P<0.05),3组FT4和TSH水平比较差异均无统计学意义(P>0.05)。低T_3亚组入院时NIHSS评分和治疗30 d后NIHSS评分均高于正常T_3亚组,△NIHSS≥2患者所占比率低于正常T_3亚组,差异均有统计学意义(P<0.01);低T_3亚组mRS评分高于正常T_3亚组,mRS≤1患者所占比率低于正常T_3亚组,差异均有统计学意义(P<0.05)。结论急性脑梗死合并低T_3综合征较常见,且低T_3状态与严重的神经功能缺损及预后相关。
Objective To analyze the relationship between the low T 3 level and the clinical severity and prognosis of acute cerebral infarction. Methods One hundred and ninety-nine patients with acute cerebral infarction admitted to the neurology ward were divided into mild, moderate and severe groups according to MMSE scores at admission. The levels of free T 3 (FT 3), free T4 (FT 4) and Thyroid stimulating hormone (TSH) levels. According to the level of T_3, the patients were divided into low T_3 subgroup and normal T_3 subgroup. The NIH Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) were compared between the two groups on admission and on the 30th day after discharge. Results There were significant differences in the levels of FT3 between light group, middle group and recombinant group (P <0.05). There was no significant difference in FT4 and TSH between the three groups (P> 0.05). The NIHSS score and the NIHSS score at 30 days after admission in the low T 3 subgroup were higher than those in the normal T 3 subgroup, and those in the △ NIHSS ≥ 2 subgroup were lower than those in the normal T 3 subgroup (P <0.01). The mRS score of low T 3 subgroup was higher than that of normal T 3 subgroup, and the proportion of patients with mRS≤1 was lower than that of normal T 3 subgroup (P <0.05). Conclusion Acute cerebral infarction with low T 3 syndrome is more common, and low T 3 state is associated with severe neurological deficit and prognosis.