论文部分内容阅读
[目的]调查研究中华人民共和国从业人员预防性健康检查实验室检查项目与频次,为我国制定切实可行的检查项目与频次提供科学依据。[方法]采用连续监测速率法测定血清中ALT活性,ELISA方法检测血清中HBV5项,对阳性者进行走访调查。大便培养采用统一的培养基和检验方法,按操作常规进行培养和检测。[结果]ALT活性升高并非都是HBV感染,而HBV感染不一定ALT活性升高;HBsAg阳性为新聘用的初检人员,在5年的续检人员中,HBsAg全是阴性。但是,HBsAg阴性不能排除HBV感染;大便培养检测痢疾、伤寒或副伤寒全是阴性。[结论]ALT检测对预防HBV传染没有现实意义,建议从实验室检查项目中删去;为防止隐匿性HBV遗漏,建议检测HBV5项;对抗-HBs阴性者,检测的间隔时间不少于2年;对抗-HBs阳性者,续检的间隔时间不少于5年,但不应超过10年;一年一次的大便培养检测,建议从实验室检查项目中删去,归为有碍公共卫生疾病的其他类。
[Objective] To investigate the items and frequency of preventive health examination laboratory in People’s Republic of China and provide scientific basis for formulating feasible inspection items and frequency in our country. [Method] The serum ALT activity was measured by continuous monitoring rate method. HBV5 serum was detected by ELISA method and the positive ones were investigated. Stool culture using a uniform culture medium and testing methods, according to the routine operation of the culture and testing. [Results] The ALT activity was not elevated in all patients with HBV infection, but HBV infection did not necessarily increase the activity of ALT. HBsAg positive was newly recruited as a newly recruited staff member. Of all the 5-year follow-up staff, HBsAg was negative. However, HBsAg-negative can not rule out HBV infection; stool culture to detect dysentery, typhoid or paratyphoid are all negative. [Conclusion] The detection of ALT has no practical significance for the prevention of HBV infection. It is suggested to delete it from the laboratory test items. In order to prevent the omission of occult HBV, it is recommended to detect HBV 5 items; for anti-HBs negative patients, the detection interval should be no less than 2 years ; Anti-HBs positive, the interval between the renewal of not less than 5 years, but not more than 10 years; once a year stool culture test, it is recommended to delete from the laboratory test items classified as hinder public health disease Other classes.