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兔颈动脉粥样硬化狭窄模型制备的方法很多,包括内膜空气干燥法、球囊损伤法、颈总动脉套环法、直流电刺激颈动脉外膜法、幽门螺杆菌感染法、显微缝合法、放射处理法、液氮损伤法、化学烧灼法等,不同的造模方式颈动脉粥样硬化狭窄形成的机制及病理特点各不相同。本文重点介绍颈动脉粥样硬化兔模型的制作方法及其优、缺点。
Rabbit carotid atherosclerosis stenosis model preparation methods are many, including the intima-air drying method, balloon injury, carotid artery collar method, DC stimulation of carotid artery adventitia, Helicobacter pylori infection, micro-suture method , Radiation treatment method, liquid nitrogen damage method, chemical cauterization method, different mode of formation of carotid atherosclerosis stenosis mechanism and pathological features vary. This article focuses on the production of carotid atherosclerosis rabbit model and its advantages and disadvantages.