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人们已经观察到辐射诱导的染色体畸变中有明显的不完全易位存在。由于一些易位片段太小,可能不会被荧光原位杂交(FISH)的全染色体染色所检测到,因此,研究了用泛端粒肽核酸(PNA)探针和全染色体DNA特异探针的联合FISH检测辐射诱导的人淋巴细胞完全和不完全染色体互换。方法:培养
It has been observed that there are obvious incomplete translocations in radiation-induced chromosome aberrations. Since some of the translocations are too small to be detected by whole chromosome staining with fluorescence in situ hybridization (FISH), the use of pan-telomere nucleic acid (PNA) probes and whole-chromosome DNA-specific probes Combined FISH detection of radiation-induced human lymphocytes with complete and incomplete chromosomal swap. Method: Culture