论文部分内容阅读
目的探讨甘精胰岛素联合二甲双胍治疗2型糖尿病的临床疗效。方法选取2型糖尿病患者66例,将其随机分为观察组和对照组各33例,观察组患者服用二甲双胍+甘精胰岛素皮下注射治疗;对照组患者仅服用二甲双胍进行治疗,两组患者治疗16周后,检测空腹血糖(FBG)、餐后2 h血糖(2 h BG)、C肽水平及糖化血红蛋白(Hb A1c)。结果两组患者经治疗后FBG、2 h BG、Hb A1c均明显下降,与治疗前比较差异有统计学意义(P<0.05),同时观察组较对照组下降明显(P<0.05)。观察组患者C肽水平明显高于对照组(P<0.05)。结论甘精胰岛素联合二甲双胍具有良好的降糖效果,同时能改善胰岛功能,减少低血糖发生,安全有效。
Objective To investigate the clinical efficacy of glargine plus metformin in the treatment of type 2 diabetes. Methods Sixty-six patients with type 2 diabetes were randomly divided into observation group (33 cases) and control group (33 cases). Patients in observation group were treated with subcutaneous injection of metformin and insulin glargine, while those in control group were treated with metformin only. Afterwards, fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h BG), C peptide and Hb A1c were detected. Results After treatment, the FBG, 2 h BG and Hb A1c in both groups were significantly decreased compared with those before treatment (P <0.05), while the observation group decreased significantly compared with the control group (P <0.05). The level of C-peptide in observation group was significantly higher than that in control group (P <0.05). Conclusion Glargine and metformin have a good hypoglycemic effect, at the same time can improve islet function, reduce hypoglycemia, safe and effective.