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国外有关饮水氟浓度与骨折关系的报道结果不一致 ,为深入研究饮水中不同浓度的氟对人群骨折的影响 ,采用环境流行病学回顾性调查方法 ,按统一设计的调查方法与询问表 ,调查了 6个饮水氟浓度不同地区人群 (氟浓度分别为 0 2 5～ 0 34、0 5 8～ 0 73、1 0 0～ 1 0 6、1 45～ 2 19、2 6 2～ 3 5 8、4 32～ 7 97mg L)的骨折发生情况及其影响因素。内容包括 :氟暴露水平、骨折情况、人口构成、病史、体格检查、吸烟史、饮酒史、饮水量和膳食营养等。各组≥ 5 0岁的调查人数分别为 136 3、140 7、1370、15 74、10 5 1、15 0 1人 ,共计 82 6 6人。统计分析结果表明 ,饮水中的氟是其主要摄氟来源。 6组人群的全部骨折率分别为 7 41%、6 40 %、5 11%、6 0 4%、6 0 9%和 7 40 % ;自然骨折率分别为 3 0 1%、2 2 1%、1 31%、1 6 5 %、1 43%和 3 6 6 % ,二者均与饮水氟浓度之间呈现U型曲线相关关系。其中以饮水氟为 1 0 0～ 1 0 6mg L组人群的骨折率最低 ,与最低和最高饮水氟组的骨折率比较有显著性差别 (P <0 0 1)。 6组人群髋部骨折率依次为 0 37%、0 43%、0 37%、0 89%、0 76 %和 1 2 0 % ,虽未出现U型曲线关系 ,但仍以饮水氟为 4 32～ 7 97mg L组人群的髋部骨折率最高 ,显著高于 1 0 0～ 1 0 6m
Foreign reports on the relationship between drinking water fluoride concentration and fracture results inconsistent, in-depth study of different concentrations of fluoride in drinking water fractures in the population, using environmental epidemiological retrospective survey method, according to the unified design of the survey methods and questionnaires to investigate Six drinking water fluoride concentrations in different regions of the population (fluoride concentrations were 0 2 5 ~ 0 34,0 5 8 ~ 0 73,1 0 0 ~ 1 0 6,1 45 ~ 2 19,2 6 2 ~ 3 5 8,4 32 ~ 7 97mg L) fractures and its influencing factors. Content includes: fluoride exposure level, fracture, demographic composition, medical history, physical examination, smoking history, history of drinking, drinking water and dietary nutrition. The number of persons surveyed ≥50 years old in each group was 136 3,140 7,1370,15 74,105 1,150 1 respectively, a total of 82 6 6 people. Statistical analysis shows that fluorine in drinking water is the main source of fluoride. The total fracture rates of the 6 groups were 7 41%, 6 40%, 5 11%, 60 4%, 60 9% and 7 40% respectively. The natural fracture rates were 301%, 21 2% 1 31%, 1 65%, 1 43% and 36 6%, respectively. Both of them showed a U-shaped curve correlation with the fluoride concentration in drinking water. Among them, the rate of fractures was the lowest among the groups with drinking water fluoride of 100-600 mg L, and there was a significant difference compared with the lowest and highest drinking water group (P <0.01). The rate of hip fracture in the 6 groups was 0 37%, 0 43%, 0 37%, 0 89%, 0 76% and 120 2% respectively. Although there was no U-shaped curve, ~ 7 97mg L group of hip fracture rate was highest, significantly higher than 1 0 0 ~ 1 0 6m