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目的观察注射用醋酸亮丙瑞林(GnRHa)对特发性中枢性性早熟(ICPP)女童的临床疗效。方法对45例ICPP女童给予注射用醋酸亮丙瑞林治疗,每4周注射1次,治疗12个月。观察分析治疗前后患儿第二性征、子宫、卵巢、雌二醇(E2)、黄体生成素(LH)、促卵泡激素(FSH)、骨龄(BA),预测成人身高的变化及药物不良反应。结果 45例患儿治疗后乳房、子宫、卵巢体积均有缩小,E2、LH、FSH较治疗前显著降低,骨龄成熟减缓,骨龄/年龄(BA/CA)值下降,预测成人身高增加(4.5±0.4)cm,与治疗前相比,差异具有统计学意义(P<0.05)。结论注射用醋酸亮丙瑞林能显著有效抑制特发性中枢性性早熟女童性腺轴及第二性征发育,延缓骨龄成熟,达到改善性早熟患儿成年终身高的目的。
Objective To observe the clinical efficacy of injecting leuprolide (GnRHa) in girls with idiopathic central precocious puberty (ICPP). Methods Forty-five ICPP girls were given leuprolide acetate injection and injected once every four weeks for 12 months. The changes of second sexual characteristics, uterus, ovary, estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and bone age (BA) in children before and after treatment were observed and analyzed to predict the adult height changes and adverse drug reactions . Results After treatment, the volume of breast, uterus and ovary in all 45 cases were reduced. The serum levels of E2, LH and FSH were significantly lower than those before treatment, the age of mature bone was slowed down and the value of BA / CA was decreased. 0.4) cm, compared with before treatment, the difference was statistically significant (P <0.05). Conclusions Leuprolide acetate injection can significantly and effectively inhibit the development of gonadal axis and secondary sexual characteristics in idiopathic precocious puberty girls and delay the maturation of bone age, so as to achieve the aim of improving the adult height of children with precocious puberty.