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目的探讨联合检测类风湿因子(RF)和抗环瓜氨酸肽抗体(CCP)对于类风湿性关节炎(RA)的临床诊断价值。方法选择2011年5月-2012年12月间在院治疗的患者177例作为研究对象,其中96例早期疑似患者作为参照组,病程超过2年的患者81例作为观察组,对患者抗CCP选用酶联免疫吸附法(ELISA)进行定量检测,对患者RF选用免疫散射比浊法进行定量检测,比较并分析上述二者检测所得结果。结果参照组患者RF、CCP抗体以及二者联合检测结果的阳性检出率分别为55.21%、46.01%、69.94%;观察组三者阳性检出率分别为53.73%、46.27%、73.13%。组内单项检测结果与联合检测结果比较差异有统计学意义(P<0.05)。结论对患者RF和CCP抗体的联合检测能够有效提高RA诊断率,具有积极的临床意义。
Objective To investigate the clinical value of combined detection of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (CCP) in rheumatoid arthritis (RA). Methods A total of 177 patients treated in our hospital from May 2011 to December 2012 were selected as the study subjects, of which 96 patients with early-stage suspected disease were the reference group and 81 patients with disease over 2 years as observation group. The patients were treated with anti-CCP Enzyme-linked immunosorbent assay (ELISA) for quantitative detection, RF immunohistochemical detection of turbidimetric method for quantitative detection, comparison and analysis of the results of the two tests. Results The positive rates of RF, CCP and the combined detection of the two groups were 55.21%, 46.01% and 69.94% respectively in the reference group. The positive rates in the observation group were 53.73%, 46.27% and 73.13% respectively. There was a significant difference between the single test results and the combined test results (P <0.05). Conclusions The combined detection of patients’ RF and CCP antibodies can effectively improve the diagnostic rate of RA, which has a positive clinical significance.